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The federal court decision paves the way for the nation's first supervised injection site to open in Philadelphia. The Justice Department argued that it amounted to "in-your-face illegal activity."
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The Justice Department has mounted a legal challenge to block the effort, claiming such a site violates federal drug laws and would enable opioid users.
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The U.S. government is intervening to stop the creation of a medical facility in Philadelphia where people could inject heroin without risk of overdose. Canada and Europe already have such sites.